April 1, 1996 -
Tim Horn -
... the brand name of Hoffmann-La Roche's saquinavir. But Brigette has yet to hand it in ... protease inhibitor is the best and whether taking saquinavir may limit my options even further in the ... viral load somewhat. But when he went on saquinavir last August -- in combination with the other two ... originated with the evidence, acknowledged by Roche, that saquinavir is so poorly absorbed by the body that ... ritonavir -- provide much more dramatic antiviral effects than saquinavir, and ritonavir appears to actually extend survival ( ...
http://www.poz.com/articles/250_1783.shtml
October 1, 1994 -
Mike Barr -
... Roche's new study comparing its protease inhibitor saquinavir in combination with AZT to the two combined ... which was then compared to AZT with ddC. Saquinavir holds promise but the study results should be ... to compare the two control arms, AZT with saquinavir and AZT with ddC. This implies, then that ... the more important comparison, AZT plus ddC plus saquinavir against the two two-drug combinations, because each ... anecdotes. Even so, they are bizarre. AZT with saquinavir induced a higher CD4 cell rise for ...
http://www.poz.com/articles/2171_16504.shtml
July 1, 1998 -
David Stokes -
... double protease inhibitor (PI) combo of ritonavir and saquinavir. Within two weeks, my viral load plummeted to ... expected in late 1998. Fortovase (soft-gel cap saquinavir), a new PI from Hoffmann–La Roche, is ... an improved version of Invirase (hard-gel cap saquinavir), the first PI on the market. The company ... is 10 times better absorbed than the old saquinavir, but half that increase is due to a ... make it a bust for many who tried saquinavir or failed earlier PIs. Amprenavir (141W94) is ...
http://www.poz.com/articles/229_7231.shtml
October 1, 1997 -
Rick Loftus -
... Third at bat: A combination of ritonavir and saquinavir (Invirase). "It failed miserably. Within four weeks my ... inhibitors. For example, delavirdine boosts blood levels of saquinavir 2- to 14-fold. Delavirdine also increases Crixivan ... We do know that nevirapine lowers Crixivan and saquinavir blood levels. Be aware that trials of combos ... used to boost levels of the poorly absorbed saquinavir. However, data presented at the Retrovirus Conference last ... For example, nelfinavir can boost levels of either saquinavir or Crixivan. Not all protease duets are ...
http://www.poz.com/articles/245_1759.shtml
February 16, 2006 -
... if used by HIV-positive pregnant women. Invirase (saquinavir soft gel capsules or tablets) boosted with low ... women using Fortovase (800mg) an older version of saquinavir combined with Norvir (100mg), both given twice a ... Less is known about the only form of saquinavir (Invirase) now on the market, although some data ... 100mg Norvir, taken twice a day, achieves adequate saquinavir levels during pregnancy. No evidence of harm to ... when taken during pregnancy. When Fortovase was available, saquinavir was a preferred protease inhibitor to use ...
http://www.aidsmeds.com/articles/Pregnancy_4907.shtml
September 1, 1997 -
John Hammond -
... by John Hammond Hoffman-La Roche, maker of saquinavir (Invirase), stands accused of shoddy, if not shady ... HIV and can quickly cause resistance. “Had saquinavir become the drug of choice, a public-health ... ” said medical director Dr. Laurent Fischer. “Saquinavir was the first protease inhibitor, and there was ... it.” A tiger in the test tube, saquinavir has absorption hitches that earned it a rep ...
http://www.poz.com/articles/244_11922.shtml
December 1, 1997 -
Rick Loftus -
... all. Stanford University researchers have found that missing saquinavir doses for only two days results in rapid ... effectiveness. Examples are ddI-hydroxyurea, delavirdine-indinavir, delavirdine-saquinavir, ritonavir-saquinavir, nelfinavir-saquinavir and nelfinavir-indinavir. Try to select drugs to ...
http://www.poz.com/articles/drugs_arv_fail_246_12883.shtml
April 1, 1996 -
Tim Horn -
... companies have products in earlier stages of development): Saquinavir (Invirase) from Hoffman-La Roche: The only protease ... by the body. (It is important to take saquinavir after a full fatty meal, and a preliminary ... produce cross-resistance to ritonavir and possibly to saquinavir. And one study found three percent of those ... Laboratories: While its antiviral activity appears stronger than saquinavir and somewhat weaker than indinavir, ritonavir is the ...
http://www.poz.com/articles/250_1786.shtml
February 1, 2008 -
... magazine covering HIV and AIDS, click here. Invirase (saquinavir) en español Pronunciation(s): IN-ver-ase ... in 1995. Invirase is the only version of saquinavir, the generic name for this protease inhibitor, available in the United States. Another version of saquinavir, Fortovase, was approved in 1997. However, with improvements made to the Invirase version of saquinavir, there is no longer a need for Fortovase ...
http://www.aidsmeds.com/archive/Invirase_1558.shtml
January 3, 2008 -
Índice de lecciones Invirase (saquinavir, SQV) ¿Qué es Invirase? Invirase es un ... única version disponible en los Estados Unidoos de saquinavir, el nombre genérico de este inhibidor de la proteasa. Fortovase, otra versión de saquinavir, fue aprobada en 1997. Sin embargo, con las ... realizadas a Invitase, la otra versión de saquinavir, ya no es necesario usar Fortovase (la venta ...
http://www.aidsmeds.com/archive/Invirase_1569.shtml
